The polyphenol mechanisms that modulate the response to food allergy could be summed up as follows: (i) potential interactions between polyphenol allergens and the digestive tract and bioaccessibility; (ii) interactions between polyphenol allergens and the epithelial barrier may affect absorption and transport across the barrier; (iii) Polyphenols can improve the functioning of epithelial cells and can also impact the abnormal regulation of T cells; and (iv) APC and IgE antigen recognition could be hindered by polyphenol allergen interactions (Figure 3). Here, IGHE is linked to food allergy.