They play a key role in the development of allergic disorders such as asthma, allergic rhinitis, and atopic dermatitis because they are quickly activated by TSLP, IL-33, and IL25, and they release large quantities of traditional Th2 cytokines IL-4, IL-5, IL-9, and IL-13 [91,92]. The gene discussed is TSLP; the disease is atopic eczema.