RAP2A and colorectal cancer: Furthermore, the network’s top 20 KEGG terms were inflammatory bowel disease, central carbon metabolism in cancer, pancreatic cancer, inhibitor resistance of EGFR tyrosine kinase, expression of PD-L1 and PD-1 checkpoint pathway in cancer, colorectal cancer, prostate cancer, proteoglycans in cancer, breast cancer, hepatitis B, lipid and atherosclerosis, and the signaling pathways were AGE-RAGE in diabetic complication, C-type lectin receptor, T cell receptor, FoxO, JAK-STAT, Rap2, MAPK, PI3K-Akt, and pathways in cancer (Figure 4E).