Abnormal methylation of the RASSF1, GSTP1, p14, CDH1, APC, RUNX3, SOCS1, p15, MGMT, SFRP1, WIF1, PRDM2, DAPK1, RARβ, hMLH1, p73, DLC1, p53, SPINT2, OPCML, and WT1 genes in the tumor tissues of HCC patients can be used as a marker to predict the incidence and survival rate of HCC patients [67]. The gene discussed is RUNX3; the disease is hepatocellular carcinoma.