In addition, while some improvements in FPG, CGM glucose levels, glucose tolerance, insulin levels, beta cell function, and insulin sensitivity and resistance were observed post TRE in some other studies of overweight or obese adults and obese subjects with a high risk of T2D (also independently of weight change and reducing caloric intake), significant improvements in glycemic parameters and insulin levels were found in subjects with elevated baseline FPG, HbA1c, and/or insulin levels [25,42,43,44,46,49,50,51,54,62]. This evidence concerns the gene INS and type 2 diabetes mellitus.