Nine patients (35% of total) had prior diagnosis of mild systemic essential hypertension (HTN) and received antihypertensive treatment including angiotensin-converting enzyme inhibitor or angiotensin receptor blocker (eight patients), beta blocker (two patients), calcium channel antagonist (one patient), and non-potassium-sparing diuretic (two patients). The gene discussed is ACE; the disease is hypertensive disorder.