In studies of neuroblastoma cell lines (SK-N-AS and SW620), another linear furanocoumarin xanthotoxin (8 MOP) was found to block DNA replication and trigger apoptotic cell death through both extrinsic and intrinsic apoptosis pathways and downregulation of pro-survival PI3K/AKT signaling [30]. Here, AKT1 is linked to neuroblastoma.