High glucose regulates tau hyperphosphorylation and neuronal apoptosis through the TLR9-P38MAPK signalling pathway [36], and the hyperphosphorylation of tau protein and sustained hyperactivation of mTOR signalling in hyperglycaemia may be associated with the inhibition of caveolin-1 (Cav-1) [37]. This evidence concerns the gene MAPT and Hyperglycemia.