KEGG enrichment analysis showed that differentially up-regulated miRNAs were widely distributed in the top five pathways of hepatocellular carcinoma, lysosome, microRNAs in cancer, transcription misregulation in cancer, and Wnt signaling pathway, and the differentially down-regulated miRNAs were extensively distributed in the top five pathways of the TNF signaling pathway, vivion flavivirus, virion–human immunodeficiency, small cell lung cancer, and phosphatidylinositol signaling system (Figure 4C,D). Here, TNF is linked to hepatocellular carcinoma.