This study compared the expression levels of miR-4516, Wnt 8B, FZD2, DVL3, FOSL1, CDK1, CDK2, CCNA1, and CCNB1 in primary LUAD tumor tissue with those in normal lung tissue using data from The Cancer Genome Atlas (TCGA) database to assess the consistency of our findings with the human sample. The gene discussed is FZD2; the disease is neoplasm.