TNF and immunodeficiency disease: KEGG enrichment analysis showed that differentially up-regulated miRNAs were widely distributed in the top five pathways of hepatocellular carcinoma, lysosome, microRNAs in cancer, transcription misregulation in cancer, and Wnt signaling pathway, and the differentially down-regulated miRNAs were extensively distributed in the top five pathways of the TNF signaling pathway, vivion flavivirus, virion–human immunodeficiency, small cell lung cancer, and phosphatidylinositol signaling system (Figure 4C,D).