LPS triggers TOP1-binding arginine/serine-rich protein (TOPORS) via the TLR4-TRIF pathway, influencing the transcription of the tumor suppressor scaffold/matrix attachment region binding protein 1 (SMAR1) in CRC.SMAR1, an STAT3 repressor, influences tumor growth and macrophage polarization towards M1 phenotype, highlighting TOPORS as a potential regulator in CRC [93]. The gene discussed is STAT3; the disease is neoplasm.