NOX1 and colonic neoplasm: LPS induces a transient ROS increase, upregulates Nox1/Nox2, and activates the PI3K/Akt pathway, facilitating CRC cell adhesion to collagen I. The LPS-Nox1 redox signaling axis significantly enhances colon cancer cell metastatic potential, underscoring the importance of targeting Nox1 to mitigate CRC metastasis [127].