Quinolinic acid affects the TME of gliomas by acting on N-Methyl-D-aspartic acid (NMDA) receptors and the forkhead box O1 (Foxo1)/peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway, inducing a tumor-supportive phenotype in macrophages. The gene discussed is FOXO1; the disease is central nervous system cancer.