Of the five myokines tested, four were significantly elevated in patients with PAD compared to those without PAD based on their median [IQR] plasma concentrations: FGF-23 (15.33 [IQR 10.43–23.67] vs. 12.19 [IQR 9.41–17.39] pg/ml, p < 0.001), TRAIL-R2 (32.76 [IQR 24.37–45.84] vs. 25.65 [IQR 19.40–35.12] pg/ml, p < 0.001), IL-7 (3.78 [IQR 3.14–5.05] vs. 3.41 [IQR 2.88–4.21] pg/ml, p = 0.001), and MCP-1 (98.66 [IQR 69.15–124.90] vs. 88.27 [IQR 67.44–115.88], p = 0.031) (Table 2). The gene discussed is FGF23; the disease is peripheral arterial disease.