Moreover, anti-TIF1γ-seropositive DM patients have a higher risk of severe disease, flagellar erythema, V-neck sign, and overall lower survival [3], while interstitial lung disease, Raynaud’s phenomenon, calcinosis, and joint involvement are less common in anti-TIF1γ-positive patients [9,10]. This evidence concerns the gene TRIM33 and dermatomyositis.