However, the BRCA1 and BRCA2 PVs coinheritance, in the population-based Israeli national breast cancer cohort, was described in 2.2% of all carriers [12], and 17 double heterozygotes for CPGs were detected in a breast cancer cohort of people of Slavic ancestry which included 5391 patients [13]. This evidence concerns the gene BRCA1 and breast cancer.