Although we found a statistically significant association between rare binned HLA-DPB1 alleles (HLA-DPB1*09:01, HLA-DPB1*10:01, HLA-DPB1*106:01, HLA-DPB1*18:01, HLA-DPB1*20:01, HLA-DPB1*26:01, HLA-DPB1*28:01, HLA-DPB1*296:01, and HLA-DPB1*55:01) and young age at cancer diagnosis, additional investigation for these HLA alleles in a large cohort of LSVH is required to further complement and validate our findings. The gene discussed is HLA-DPB1; the disease is cancer.