WT1 and renal cell carcinoma: The study design of the present investigation, i.e., a retrospective IHC assessment of comparative immunoexpression patterns for unconventional biomarkers in proper RCC tumor tissue and tumor-adjacent HRT, allows only speculative observations about the pathogenic significance and biological implications of WT1 transcripts and pre-mutagenic TDs in RCC carcinogenesis, progression and therapeutics.