Administration of prostaglandin E2 in COX-2-deficient mice partially improved anastomotic leak rates, while treatment of ANXA1 KO mice with Ac2-26 nanoparticles reduced colitis activity and increased weight recovery following surgery.<h4>Conclusions</h4>our findings provide new insights into improving intestinal wound healing by amplifying the aforementioned genes using appropriate gene therapies. This evidence concerns the gene ANXA1 and colitis.