The potential role of obesity as an aggravating factor that contributes to psoriasis severity found confirmation in an obese mice model demonstrating the exacerbation of psoriasis-like lesions after imiquimod induction that was associated with an enhanced expression of IL-17A, IL-22, IL-23p19, IL-17C, and β-defensin 3 [49]. The gene discussed is IL22; the disease is psoriasis.