MTOR and tuberous sclerosis: Among these, the phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/Akt and tuberous sclerosis (TSC)/mammalian target of rapamycin (mTOR) pathways have been extensively studied because they are critical regulators of ovarian folliculogenesis [1] and, in a broader perspective, of other pathophysiological mechanisms [2].