AKT1 and cancer: A study on epithelial OC-derived cells and cancer cell lines—namely CaOV3 and OVCAR3—demonstrated the pivotal role of Akt1 in the Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, through the extrinsic apoptosis-inhibition of the initiator caspase 8 and the intrinsic apoptosis-interference with Bid cleavage (truncated Bid, tBid).