PIK3CA and cancer: Likewise, patient-derived OC spheroids cultured in vitro with LY-294002—a PI3K-Akt dual kinase inhibitor—showed a significant decrease in cancer stemness and chemoresistance to cisplatin [141], and resveratrol-treated OC cells SKOV-3 displayed increased apoptosis and induced cell cycle arrest through Akt suppression in vitro [142].