Thus, the overexpression of miR-18b-5p mitigated sex hormone imbalances and reduced pathological damage in the ovaries of PCOS rats, indicating that the miR-18b-5p/PTEN axis may regulate the PI3K/Akt/mTOR pathway in the progression of PCOS [93]. The gene discussed is AKT1; the disease is polycystic ovary syndrome.