Antiphospholipid antibody syndrome (APS) is characterized by venous or arterial thromboembolism, poly-embolism and hemorrhagic risk in the presence of the antiphospholipid antibodies (aPL) lupus anticoagulant (LA), anti-cardiolipin antibodies (aCL) or anti-beta2glycoprotein (B2GPI). The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.