It has been reported that increased SET7/9 expression in rat mesangial cells under TGF-β stimulation promotes the expression of P21 [37] and ECM-related genes (COL1A1, CTGF, PAI-1) [38] by recruiting H3K4me1 enriched in the promoter regions of these genes, thereby mediating renal fibrosis. Here, CDKN1A is linked to renal fibrosis.