ARSB and hereditary disease: Mucopolysaccharidosis types I-H (Hurler), II (Hunter), and VI (Maroteaux–Lamy) are genetic disorders caused by enzyme deficiencies (α-L-iduronidase, iduronate-2-sulfatase, N-acetylgalactosamine-4-sulfatase) leading to glycosaminoglycan build-up, affecting bone metabolism, jaw growth, TE, and potentially life-threatening vital organ damage.