A ~3-kb deletion-type DNA copy number variation (CNV, esv3587290) located at intron 7 of the <i>VANGL1</i> gene (1p13.1, MIM*610132) has been proposed as a genetic factor in lupus nephritis (LN) development in adult systemic lupus erythematosus (SLE) patients across European-descent populations, but its replication in other ethnicities has been inconsistent and its association with LN in childhood-onset SLE (cSLE) remains unknown. The gene discussed is VANGL1; the disease is systemic lupus erythematosus.