Also, the overexpression of miR-17-92 in cardiac and smooth muscle tissues induced hypertrophic cardiomyopathy and arrhythmia by directly repressing the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and connexin 43 (Cx43) [57] in animals. This evidence concerns the gene GJA1 and hypertrophic cardiomyopathy.