NRF2 further supports NADPH production by positively regulating principal NADPH-generating enzymes, like glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (PGD) and isocitrate dehydrogenase 1 (IDH1), in primary cortical astrocytes, lung cancer cells, and mouse small intestine and liver [107,112,113,114]. Here, G6PD is linked to lung cancer.