APP and Alzheimer disease: The flavone apigenin (at the dose of 40 mg/kg) administered in the 2 × FAD mouse model (AD-linked mutations in genes coding for APP and PS1) for 12 weeks alleviated learning and memory disorders associated with AD similarly to how 7,8-DHF alleviated Aβ burdens, inhibited the amyloidogenic process, oxidative stress, and restored the ERK/CREB/BDNF pathway in the cerebral cortex of mice [216].