SPP1 and gastric cancer: The abilities of HGC27 (a human cell line derived from the metastatic lymph node of GC) and NCI-N87 (a cell line derived from a male GC patient in 1976) cells to proliferate and migrate was severely hindered by the downregulation of secreted phosphoprotein (SPP1), which was observed following small interfering RNA (siRNA) transfection.