In this study, we observed that SOCS3 levels are significantly upregulated in (a) the pre-Bötzinger Complex (preBötC) of the brainstem and (b) the ventral horn of both cervical and lumbar spinal cord of ALS mice, which are accompanied by increased astrogliosis and decreased neurons, and are related to the neurodegeneration stage of ALS from the pre-symptomatic to early symptomatic stage. This evidence concerns the gene SOCS3 and amyotrophic lateral sclerosis.