RBFOX3 and amyotrophic lateral sclerosis: The large NeuN+ neurons found in the ventral horn were significantly decreased by 26.5 percent at 9 weeks of age (Figure 5E,F,P) and decreased by 49 percent at 16 weeks of age (Figure 5K,L,P) in the lumbar spinal cord of ALS mice, compared to what we found in age-matched WT mice (Figure 5B,H,P).