RBFOX3 and amyotrophic lateral sclerosis: In addition, we used IHC to detect SOCS3 and NeuN+ (a marker for neurons) neurons in the brainstem of ALS mice and found that SOCS3 was significantly increased at the pre-symptomatic stage (9 weeks old, Figure 3D,F,K,M) and became more robust at the early symptomatic stage (16 weeks old, Figure 3G,I,L,M), when compared to WT mice.