SOCS3 and amyotrophic lateral sclerosis: SOCS3 was significantly increased by 3 times at 9 weeks of age (Figure 5D,F,M,O), and increased by 8.2 times at 16 weeks of age (Figure 5J,L,N,O) in the lumbar spinal cord of ALS mice, as compared to age-matched WT mice (Figure 5A,G,O).