Given that SOCS3 was highly upregulated in the neurons of the cervical spinal cords of ALS mice at the age of both 9 and 16 weeks (Figure 4), we next examined whether SOCS3 levels are upregulated in the lumbar spinal cords which modulates the hindlimbs function of ALS mice. Here, SOCS3 is linked to amyotrophic lateral sclerosis.