In the preBötC, ALS-upregulated SOCS3 (Figure 2D,G,K,L) was associated with increased and reactive GFAP+ astrocytes (Figure 2E,H,K,L,N), indicating that the neuroinflammation already started before the disease onset as early as 9 weeks of age as examined, and kept ongoing after disease onset. The gene discussed is SOCS3; the disease is amyotrophic lateral sclerosis.