SOCS3 was significantly increased by 12.5 times at 9 weeks of age (Figure 4D,F,M,O), and further increased by 25.3 times at 16 weeks of age (Figure 4J,L,N,O) in the cervical spinal cord of ALS mice, as compared to age-matched WT mice (Figure 4A,G,O). Here, SOCS3 is linked to amyotrophic lateral sclerosis.