SOCS3 and amyotrophic lateral sclerosis: The studies of the spatiotemporal expression of SOCS3 in ALS not only suggest the involvement of the neuroinflammation-associated non-cell-autonomous pathway in the progressive ALS pathogenesis, but also provide a potential therapeutic target for balancing an uncontrolled neuroinflammatory response through the manipulation of SOCS3 levels to regulate ALS progression.