Results showed that the four TME-MDGs, AJAP1 (Figure 13D), HOXB9 (Figure 14E), MYH14 (Figure 14F), and SLC6A19 (Figure 14G), were downregulated in ccRCC tissues (p < 0.01), which is consistent with bioinformatics analyses. The gene discussed is AJAP1; the disease is nonpapillary renal cell carcinoma.