However, LRP5 is active after hypercholesterolemia or ischemia [3,26,30,31], indicating that particular RNA splicing in the Lrp5 transcript must occur exclusively in the brains of Lrp5−/− mice to generate an Lrp5 transcript similar to full-length Lrp5-201 that can generate a functional protein. The gene discussed is LRP5; the disease is familial hypercholesterolemia.