APP and Alzheimer disease: Moreover, irradiation by 56Fe (0.5 Gy, 151.4 keV/μm) increased the locomotor activity of APP/PS1 (transgenic model of Alzheimer’s disease) female mice, as well as exploratory activity (rearing) of C57BL/6J mice in the open field test, and improved the motor coordination of APP/PS1 male mice in the rotarod test [6].