IGFBP2 and neoplasm: When selecting the LUAD_CPTAC_mRNA dataset to analyze changes in RNA levels of these reader proteins, the results show that IGF2BP1/3 and YTHDF1/2 RNA levels are significantly higher in tumor tissues compared to normal tissues (all p < 0.001, Figure 3B), whereas IGFBP2, YTHDC1/2, and YTHDF3 are expressed higher in normal tissues (all p < 0.001, Figure 3B).