According to the involvement of DEGs in signaling pathways, it can be assumed that the key role in these processes may be played by the genes Adra2b, Ccl9, Ccl24, Ccn1, Esr1, Fzd5, Gh1, Itgb3, Met, and Ramp3, three of which are associated with hypertension, and the Esr1 gene encodes a transcription factor. Here, ESR1 is linked to hypertensive disorder.