These categories include WNT (WNT1, WNT3A, WNT6, AXIN2, TNF2, MMP7), Alzheimer disease presenilin (WNT1, WNT3A, WNT6, MMP7), cadherin (WNT1, WNT3A, WNT6) and Notch (LFNG, HES1) signaling pathways. Here, LFNG is linked to early-onset autosomal dominant Alzheimer disease.