Additionally, in certain subgroups, including patients with age < 58 years old, male gender, CEA ≤ 2.5 ng/mL, tumor diameter > 44.0 mm, tumor free margin ≥ 50 mm, tumor invasion pT4, no lymph node metastasis, poorly differentiated tumors, and right-sided tumors, no significant association with PFS was observed. This evidence concerns the gene CEACAM5 and neoplasm.