Similarly to the TNF cytokine and Tag7-Hsp70 or 17.1-Hsp70 cytotoxic complexes, the 17.1-Mts1 complex interacts with the TNFR1 receptor and induces alternative cytotoxic processes in tumor cells: apoptosis and necroptosis. The gene discussed is PGLYRP1; the disease is neoplasm.