Additionally, as described in cardiac hypertrophy, it has been reported that the activation of Mef2c transcription is mediated both by CALM1 and ERK1/2 -extracellular signal regulated kinases 1 and 2, a signal transducer in the family of mitogen activated protein kinase, MAPK- [40,41,42,43,44]. This evidence concerns the gene MAPK3 and cardiac hypertrophy.