NOTCH1 and acute lymphoblastic leukemia: Although our study has several limitations (one model of T-ALL, NOTCH1 dependent T-ALL, limited number of samples, targeted metabolomics), the reduced number of confounding factors in our model, which may influence serum/plasma metabolomics in human samples (disease stage, gender, drug intake, and environmental factors), may help in better identifying the real metabolic differences between leukemia patients and healthy controls.