Analyzing gene expression data from a similar NOTCH1-induced murine T-ALL model (where overexpression of an activated, intracellular form of Notch1 (ICN1) in transplanted Lin-negative murine hematopoietic cells leads to the development of an abnormal DP T cell subset at 2 weeks of transplantation followed by the rise of a highly tumorigenic DP leukemic population at 6–8 weeks of transplantation [18]), we found Bcat1 to be highly upregulated in leukemic DP cells compared to normal DP cells. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.