GPER1 and ovarian serous adenocarcinoma: Researchers have previously utilized G-1, a selective agonist of GPER, to investigate its effects on proliferation in OVCAR3 (a high-grade serous cancer, HGSC, with HGSC defined as a fast-growing and rapidly spreading serous cancer that is the most common type of serous ovarian cancer) and SKOV3 (a non-high-grade serous cancer, non-HGSC, with non-HGSC being rarer and causing slow-growing tumors) cells [5,16].