Circulating IGF-1 [231] and IGFBP-2 [233] are typically considered to be pro-tumorigenic; IGF-1 exhibits pro-proliferative and anti-apoptotic properties [234,235,236,237], while IGFBP-2 enhances cancer cell survival, proliferation, invasion, and migration, as well as intra-tumoral angiogenesis [233]. This evidence concerns the gene IGFBP2 and cancer.