Additionally, IL-15 infusion into a glioma-bearing mouse brain suppressed tumor growth, which depended on intensified intra-tumoral infiltration of natural killer cells [204], and in a mouse model of pancreatic cancer, IL-15 limited tumor growth and improved survival; further, low-intensity treadmill exercise increased the number of circulating CD8+ T-lymphocytes as well as intra-tumoral infiltration; the observed effects depended on IL-15 [117]. Here, IL15 is linked to familial pancreatic carcinoma.