In a subsequent 38-month prospective study by the same authors involving 314 patients with type 2 diabetes and diabetic nephropathy (including 42 with ESRD), the impact of 19 SNPs in six genes related to enzymes metabolizing glycolytic intermediates (such as transketolase, transaldolase, transketolase like-1, fructosamine 3-kinase, glyoxalase 1, and glucose-6-phosphate dehydrogenase) was assessed. The gene discussed is TKT; the disease is type 2 diabetes mellitus.