In fact, the prediabetic group differed from the high-risk groups identified in cross-sectional or prospective observational studies with regard to IGFBP-1; according to a Swedish study, an increase in IGFBP-1 was observed in individuals with prediabetes as they approached overt type 2 diabetes [19,20]. This evidence concerns the gene IGFBP1 and type 2 diabetes mellitus.