PLEC and muscular dystrophy: As mentioned above, genetic variants in Plec have been reported to be involved in Plectin-associated diseases, including autosomal recessive generalized intermediate epidermolysis bullosa simplex 5D, autosomal dominant epidermolysis bullosa simplex 5A, Ogna type, autosomal recessive epidermolysis bullosa simplex 5B with muscular dystrophy, autosomal recessive epidermolysis bullosa simplex with pyrolic atresia, and autosomal recessive limb-girdle muscular dystrophy-17 [9,10,11].