CXCL8 and cancer: The stromal cells may also contribute to the recruitment/development of M2-like cancer-associated macrophages, and this process is cytokine-supported with regards to monocyte recruitment (e.g., CCL2 and CXCR2 ligands), differentiation (e.g., macrophage colony-stimulating factor (M-CSF)) and polarization (e.g., IL6 and CXCL8/IL8) [61].