MTOR and acute myeloid leukemia: (i) Their first cluster was associated with monocytic AML cell differentiation; this cluster was also associated with the decreased expression of Bcl-2 together with the increased expression of MCL-1 and BCL-2A1; activation of several metabolic pathways (glycolysis, oxidative phosphorylation and fatty acid metabolism); activation of PI3K-mTOR signaling and susceptibility to the inhibition of cyclin-dependent kinases.