SELL and acute myeloid leukemia: Finally, it should be emphasized that AML cells show the constitutive release of a wide range of other biologically active molecules (e.g., several extracellular matrix molecules, soluble adhesion molecules like L-selectin and ICAM1, apoptosis-regulating mediators, including the Fas ligand, and soluble forms of several cell surface receptors) [55,56,57], but it is not known whether the levels of these mediators are associated with monocytic AML cell differentiation.