Our sample-focused analysis during the latest 5-year PubMed search of clinical studies and case reports followed a triad of turning points between pancreas status and primary hyperparathyroidism (hypercalcemia-linked pancreatitis, MEN1 gene pathogenic variants, and insulin resistance) and showed a complex panel of connection elements from pathogenic factors, including biochemical, molecular, genetic, and metabolic factors, to a clinical multidisciplinary personalized approach. This evidence concerns the gene MEN1 and primary hyperparathyroidism.