Primary hyperparathyroidism, an endocrine condition causing hypercalcemia due to parathormone (PTH) producing single (accounting 80–85% of all cases) or multiple parathyroid tumors, stands for a myriad of acute and chronic clinical elements such as kidney stones (and eventually acute or chronic renal failure), bone loss and associated fragility fractures, and arrhythmia, as well as non-specific features such as dry skin, impaired sleep, headache, chest pain, fatigue/asthenia, polyuria/polydipsia, etc. [1,2]. The gene discussed is PTH; the disease is Hypercalcemia.