The CCL5 axis and its main receptor CCR5 support tumor progression through multiple mechanisms, such as increasing tumor growth, inducing extracellular matrix remodeling, enhancing tumor cell migration (metastasis formation), expanding cancer cell stemness, promoting cancer cell resistance to drugs, decreasing cytotoxicity to DNA-damaging agents, deregulating cellular energetics (metabolic reprogramming), and promoting angiogenesis, as reviewed in [24]. The gene discussed is CCL5; the disease is cancer.