APC and renal cell carcinoma: Skrypkina et al. investigated methylation of six tumor suppressor genes in 27 RCC patients and 15 healthy subjects, finding LRRC3B detection yielded a sensitivity of 74.1% and specificity of 66.7%; RASSF1 detection was a 62.9% sensitive and 93.3% specific test; FHIT detection was a 55.6% sensitive and 100% specific test; and APC detection was a 51.9% sensitive and 93.3% specific test [145].