Adaptive FAP-CAR-T cell transfer, as shown by Lo et al., lowered the amount of ECM proteins and glycosaminoglycans, reduced tumor vessel density, suppressed the growth of desmoplastic human lung cancer xenografts and syngeneic mouse pancreatic cancers in an immune-independent manner, and inhibited the growth of autochthonous pancreatic cancer [173,174]. Here, FAP is linked to familial pancreatic carcinoma.