HLA-C and neoplasm: Universal CARs that have no endogenous TCR or MHC, self-destructive CARs (CXCR2-expressing CAR-T) carrying a chemokine receptor on their surface that binds to chemokines secreted by tumor cells, self-destructive CARs expressing inducible modified human caspase 9 fused to human FK506-binding protein which provides external signals to stop their activity), and methotrexate (MTX)-conditional CAR-T cells whose antitumor effect can be modulated by MTX are currently under investigation [131,142,144,145,146,147].