Among over 600 single nucleotide polymorphisms (SNPs) in the VDR gene FokI (C/T-rs2228570 (previous name rs10735810), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232) have been most commonly analyzed for their relationship with melanoma, with Cdx2 (rs11568820), EcoRV (rs4516035), and BglI (rs739837) studied to a lower extent. This evidence concerns the gene CDX2 and melanoma.