Specifically, melanoma can produce various neuropeptides and neurohormones, such as POMC-derived MSH, ACTH and β-endorphin peptides, CRH, urocortins, enkefalis, TSH, TRH, neurotrophins, pro- and anti-inflammatory cytokines, catecholamines, serotonin, melatonin, and steroids including corticosterone and cortisol, as examples. This evidence concerns the gene POMC and melanoma.