Among the patients, 7 had a genetic risk for developing melanoma and 16 were currently taking or had previously taken immunosuppressive medication (methotrexate, azathioprine, mycophenolic acid, TNF-alpha inhibitors, prednisolone, calcineurin inhibitors, and/or chemotherapy) due to inflammatory joint disease, inflammatory bowel disease, multiple sclerosis, organ transplantation, or cancer. The gene discussed is TNF; the disease is multiple sclerosis.