TAC1 and type 2 diabetes mellitus: In a GWAS of type 2 diabetes (T2D) patients, 15 SNPs located near several novel genes (PPARD, CCDC102A, GBA3, NEDD9, GABRR1/2, RPS6KA2, TAC1, GALNTL1 and KIAA1671) on six chromosomes were putatively associated with diabetic cataract in a Taiwanese population [51], whereas, a variant in the gene for calcium voltage-gated channel subunit α-1 C (CACNA1C) was associated with diabetic cataract in a Scottish T2D cohort [158].