EPHA2 and Autosomal dominant optic atrophy and cataract: EPHA2: Concurrently, the first mutations in the human gene for ephrin type-A receptor 2 (EPHA2) on chromosome 1p were found to underlie autosomal dominant cataract and several germline variants (but not somatic variants) were associated with age-related cortical cataract mapped to the ARCC2 locus [117,118,119,120].