In addition, variants in SOX-OT (see above) and in the genes for transmembrane serine protease 5 (TMPRSS5), the long intergenic non-protein coding RNA 1412 (LINC01412), BRD4-interacting chromatin-remodeling complex-associated protein/glioma tumor suppressor candidate region gene 1 protein (BICRA/GLTSCR1), and copper metabolism domain containing 1 (COMMD1) were associated with age-related nuclear cataract at GWAS significance in Europeans and Asians [54]. The gene discussed is TMPRSS5; the disease is Age-related nuclear cataract.