MAF and coloboma of iris: MAF: Soon after mutations of the musculoaponeurotic fibrosarcoma proto-oncogene (MAF) on chromosome 16q were first discovered in families with autosomal dominant congenital (pulverulent) cataract and other ocular defects including microcornea and iris coloboma, a Maf mutation was found to underlie the dominant Opaque flecks in lens (Ofl) cataract phenotype in mice [98,99].