FOXE3 and anterior segment dysgenesis: FOXE3: Following the discovery of two missense mutations in the gene for forkhead box E3 (Foxe3) underlying the autosomal recessive dysgenetic lens (dyl) phenotype in mice first reported in 1979 [95,96], an insertion mutation was first discovered the human counterpart gene (FOXE3) on chromosome 1p in a family with autosomal recessive cataracts and anterior segment ocular dysgenesis (ASOD) [97].