While variants in or near most crystallin genes have been tentatively associated with age-related nuclear cataract, only variants in CRYAA and CRYAB (11q)—which encode the small heat-shock proteins HSPB4 and HSPB5, respectively—exceed (CRYAA) or approach (CRYAB) genome-wide significance for association with age-related nuclear cataract in multi-ethnic Asian (CRYAA) or European (CRYAB) populations [52,54]. The gene discussed is CRYAA; the disease is Age-related nuclear cataract.