Interestingly, SOX3 role is multifaceted; Turchi et al. [76] highlighted its anti-proliferative influence in plasmacytoid dendritic cells (PDC) from primary glioblastoma tumors, presenting a contrast to its previously noted contribution to cancer cell proliferation and tumor progression in different cancers, including gliomas [51,68]. The gene discussed is SOX3; the disease is glioma.